Treatment of severe imipramine poisoning.

نویسندگان

  • J A Young
  • W H Galloway
چکیده

The clinical effects and treatment of imipramine and amitriptyline poisoning have been reviewed by Giles (1963) and Steel, O'Duffy, and Brown (1967). The majority of cases are mild and recover spontaneously. The severe case is characterized by coma, convulsions, and cardiac arrhythmias. There is the added risk of respiratory depression and hypotension. Poisoning is severe if the dose of the drug ingested exceeds 20 mg/kg (Steel et al., 1967). Cairncross and Gershon (1962) have shown that the tachycardia that follows administration of these drugs in low dosage is due to vagal block. Larger doses have a direct action on the myocardium to cause AV block, extrasystoles, ventricular tachycardia, widening of the QRS complex, ST depression, and abnormal T waves. They also noted that an increase in the load on the heart potentiated this toxic effect. ECG changes have been described by Barnes, Kong, and Wu (1968) and Freeman et al. (1969).

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عنوان ژورنال:
  • Archives of disease in childhood

دوره 46 247  شماره 

صفحات  -

تاریخ انتشار 1971